Event Title

The Stabilization of Aqueous Ascorbic Acid Solutions using PAMAM Dendrimers

Location

Buller Hall

Start Date

2-26-2016 2:30 PM

End Date

2-26-2016 4:00 PM

Description

Ascorbic acid, also known as vitamin C, is an effective antioxidant and an essential human enzymatic cofactor. However, it is unstable in aqueous solution and degrades readily upon exposure to air and ultraviolet light. Thus, PAMAM (polyamidoamine) dendrimers were evaluated to stabilize dilute aqueous solutions of ascorbic acid. UV-Vis absorbance spectroscopy was used to measure the degradation over four hours, with and without the dendrimer, at varying pH values. Our data shows that PAMAM G2-Amine dendrimers significantly decrease the rate of ascorbic acid degradation, especially near physiological pH, demonstrating the effectiveness of these nanopolymers as a platform for vitamin C stabilization.

Acknowledgments

Dr. Ryan Hayes

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Feb 26th, 2:30 PM Feb 26th, 4:00 PM

The Stabilization of Aqueous Ascorbic Acid Solutions using PAMAM Dendrimers

Buller Hall

Ascorbic acid, also known as vitamin C, is an effective antioxidant and an essential human enzymatic cofactor. However, it is unstable in aqueous solution and degrades readily upon exposure to air and ultraviolet light. Thus, PAMAM (polyamidoamine) dendrimers were evaluated to stabilize dilute aqueous solutions of ascorbic acid. UV-Vis absorbance spectroscopy was used to measure the degradation over four hours, with and without the dendrimer, at varying pH values. Our data shows that PAMAM G2-Amine dendrimers significantly decrease the rate of ascorbic acid degradation, especially near physiological pH, demonstrating the effectiveness of these nanopolymers as a platform for vitamin C stabilization.