Poster Title
P-02 Analysis of Mammalian Carboxypeptidase O Expression Patterns
Abstract
Carboxypeptidase O (CPO) is a protease that cuts acidic amino acids from the carboxy termini of substrate proteins. This study aims to describe the expression patterns of CPO in small mammals. We have sampled tissue from four different species: thirteen-lined ground squirrel, eastern chipmunk, eastern mole, and northern short-tailed shrew. Samples were analyzed via Western blot using two CPO antibodies. Immunoreactive bands likely to be CPO, with molecular weights approximately 42 kDa, were seen predominantly in kidney, liver, and small intestine tissue samples. This suggests CPO could play a specific physiological function in these organs.
Thesis Record URL
Location
Buller Hall
Start Date
2-26-2016 2:30 PM
End Date
2-26-2016 4:00 PM
P-02 Analysis of Mammalian Carboxypeptidase O Expression Patterns
Buller Hall
Carboxypeptidase O (CPO) is a protease that cuts acidic amino acids from the carboxy termini of substrate proteins. This study aims to describe the expression patterns of CPO in small mammals. We have sampled tissue from four different species: thirteen-lined ground squirrel, eastern chipmunk, eastern mole, and northern short-tailed shrew. Samples were analyzed via Western blot using two CPO antibodies. Immunoreactive bands likely to be CPO, with molecular weights approximately 42 kDa, were seen predominantly in kidney, liver, and small intestine tissue samples. This suggests CPO could play a specific physiological function in these organs.
Acknowledgments
Dr. Peter J. Lyons