Event Title

The Effect of Degrading the Transcription Factor NF-κB Subunit Proteins on NF-κB’s Oncological Activity

Presenter Information

Seongmin Lee, Andrews University

Location

Buller Hall

Start Date

2-26-2016 2:30 PM

End Date

2-26-2016 4:00 PM

Description

Nuclear factor-kappa B (NF-κB) is a transcription factor that becomes functional when any two of its five component proteins (p50, p52, p65, c-Rel, and RelB) join together. Because of its involvement in oncogenesis, NF-κB is commonly subjected to modification to curb cancer growth. In this project, each component protein of NF-κB was degraded using RNAi to see if it would have any influence on glioblastoma, a form of brain cancer. It was found that degradation of p50 and p52 significantly reduced NF-κB activity while the remaining three failed to produce significant reduction.

Acknowledgments

Dr. Denise Smith

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Feb 26th, 2:30 PM Feb 26th, 4:00 PM

The Effect of Degrading the Transcription Factor NF-κB Subunit Proteins on NF-κB’s Oncological Activity

Buller Hall

Nuclear factor-kappa B (NF-κB) is a transcription factor that becomes functional when any two of its five component proteins (p50, p52, p65, c-Rel, and RelB) join together. Because of its involvement in oncogenesis, NF-κB is commonly subjected to modification to curb cancer growth. In this project, each component protein of NF-κB was degraded using RNAi to see if it would have any influence on glioblastoma, a form of brain cancer. It was found that degradation of p50 and p52 significantly reduced NF-κB activity while the remaining three failed to produce significant reduction.