Date of Award
3-28-2016
Document Type
Honors Thesis
Department
Biology
First Advisor
Peter J. Lyons
Abstract
Carboxypeptidase 0 (CPO) is a protease that cuts acidic amino acids from the carboxy termini of substrate proteins. This study aims to describe the expression patterns of CPO in small mammals. We have sampled tissue from four different species: thirteen-lined ground squirrel, eastern chipmunk, eastern mole, and northern short-tailed shrew. Samples were analyzed via Western blot using two CPO antibodies. Immunoreactive bands likely to be CPO, with molecular weights approximately 42 kDa, were seen predominantly in kidney, liver, and intestinal tissue samples. This suggests CPO could play a specific physiological function in these organs.
Recommended Citation
Bardan, Christian, "Analysis of Mammalian Carboxypeptidase O Expression Patterns" (2016). Honors Theses. 133.
https://dx.doi.org/10.32597/honors/133/
https://digitalcommons.andrews.edu/honors/133
Presentation Record URL
Creative Commons License
This work is licensed under a Creative Commons Attribution-No Derivative Works 4.0 International License.
DOI
https://dx.doi.org/10.32597/honors/133/
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