Abstract
Prostate cancer is detected by excess PSA in the bloodstream, a protein the prostate overproduces when tumors are present. In this paper, we designed an origami paper analytical device, specific to PSA using gold nanoparticles which provide a colorimetric, qualitative, inexpensive, disposable design to detect PSA. Our device separates the sample laterally to prevent back-mixing and vertically to enable addition of novel particles. The design was optimized for channel thickness, size, proper heating, type of paper involved, and amount of sample solution needed. We are currently concept-testing of PSA qualitative detection via sandwich assay to target detection levels < 100ng/mL.
Thesis Record URL
Location
Buller Hallway
Start Date
3-6-2015 2:30 PM
End Date
3-6-2015 4:00 PM
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P-08 Paper-based Biosensor for Colorimetric Detection of PSA Biomarker
Buller Hallway
Prostate cancer is detected by excess PSA in the bloodstream, a protein the prostate overproduces when tumors are present. In this paper, we designed an origami paper analytical device, specific to PSA using gold nanoparticles which provide a colorimetric, qualitative, inexpensive, disposable design to detect PSA. Our device separates the sample laterally to prevent back-mixing and vertically to enable addition of novel particles. The design was optimized for channel thickness, size, proper heating, type of paper involved, and amount of sample solution needed. We are currently concept-testing of PSA qualitative detection via sandwich assay to target detection levels < 100ng/mL.
Acknowledgments
J.N. Andrews Honors Scholar and Undergraduate Research Scholar
Advisor: Hyun Kwon, Engineering & Computer Science