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Department
Chemistry and Biochemistry
Abstract
Glioblastoma multiforme (GBM) is an aggressive form of brain cancer that originates from glial cells, which make up the supportive tissue surrounding neurons. Temozolomide (TMZ) is the current chemotherapeutic drug administered to treat GBM as it works to inhibit the growth of the cancer cells. This research study focuses on developing a method for synthesizing novel hybrid compounds that combines TMZ with various fatty acids known to have anticancer properties, forming a series of imide compounds with potential chemotherapeutic effects. Once the novel hybrid compounds are successfully synthesized, they will be tested for their anticancer properties on glioblastoma cells.
Thesis Record URL
https://digitalcommons.andrews.edu/honors/251/
Session
Department of Chemistry & Biochemistry
Event Website
https://www.andrews.edu/services/research/research_events/conferences/urs_honors_poster_symposium/index.html
Start Date
3-26-2021 2:40 PM
End Date
3-26-2021 3:00 PM
Synthesis of Novel Temozolomide-Fatty Acid Imide Hybrid Compounds for the Chemotherapeutic Treatment of Glioblastoma Multiforme
Glioblastoma multiforme (GBM) is an aggressive form of brain cancer that originates from glial cells, which make up the supportive tissue surrounding neurons. Temozolomide (TMZ) is the current chemotherapeutic drug administered to treat GBM as it works to inhibit the growth of the cancer cells. This research study focuses on developing a method for synthesizing novel hybrid compounds that combines TMZ with various fatty acids known to have anticancer properties, forming a series of imide compounds with potential chemotherapeutic effects. Once the novel hybrid compounds are successfully synthesized, they will be tested for their anticancer properties on glioblastoma cells.
https://digitalcommons.andrews.edu/honors-undergraduate-poster-symposium/2021/symposium/15
Acknowledgments
Advisor: Desmond Murray