Poster Title
P-54 Development of a Synthetic Method for Acyl Ureas from Aspirin
Abstract
The objective of this project is to develop a synthetic method for acyl ureas from aspirin and analyze the effects of various amines on the aspirin acyl urea synthesis. Acyl ureas are known to have important biological effects, such as being insecticides, antidiabetics, anticonvulsants, and sedatives. This project investigates the possible ‘hybrid’ properties of acyl ureas made from aspirin to determine whether they show unique biological activities. Our ‘one-pot’ synthetic procedure converts aspirin into its acid chloride, then an acyl isocyanate, and finally to an acyl urea using different amines. We tested fifteen different amines using our optimized reaction conditions.
Location
Buller Hall
Start Date
3-3-2017 2:30 PM
End Date
3-3-2017 4:00 PM
P-54 Development of a Synthetic Method for Acyl Ureas from Aspirin
Buller Hall
The objective of this project is to develop a synthetic method for acyl ureas from aspirin and analyze the effects of various amines on the aspirin acyl urea synthesis. Acyl ureas are known to have important biological effects, such as being insecticides, antidiabetics, anticonvulsants, and sedatives. This project investigates the possible ‘hybrid’ properties of acyl ureas made from aspirin to determine whether they show unique biological activities. Our ‘one-pot’ synthetic procedure converts aspirin into its acid chloride, then an acyl isocyanate, and finally to an acyl urea using different amines. We tested fifteen different amines using our optimized reaction conditions.
Acknowledgments
Dr. Desmond H. Murray