Poster Title
P-13 The Effect of Degrading the Transcription Factor NF-κB Subunit Proteins on NF-κB’s Oncological Activity
Abstract
Nuclear factor-kappa B (NF-κB) is a transcription factor that becomes functional when any two of its five component proteins (p50, p52, p65, c-Rel, and RelB) join together. Because of its involvement in oncogenesis, NF-κB is commonly subjected to modification to curb cancer growth. In this project, each component protein of NF-κB was degraded using RNAi to see if it would have any influence on glioblastoma, a form of brain cancer. It was found that degradation of p50 and p52 significantly reduced NF-κB activity while the remaining three failed to produce significant reduction.
Thesis Record URL
Location
Buller Hall
Start Date
2-26-2016 2:30 PM
End Date
2-26-2016 4:00 PM
P-13 The Effect of Degrading the Transcription Factor NF-κB Subunit Proteins on NF-κB’s Oncological Activity
Buller Hall
Nuclear factor-kappa B (NF-κB) is a transcription factor that becomes functional when any two of its five component proteins (p50, p52, p65, c-Rel, and RelB) join together. Because of its involvement in oncogenesis, NF-κB is commonly subjected to modification to curb cancer growth. In this project, each component protein of NF-κB was degraded using RNAi to see if it would have any influence on glioblastoma, a form of brain cancer. It was found that degradation of p50 and p52 significantly reduced NF-κB activity while the remaining three failed to produce significant reduction.
Acknowledgments
Dr. Denise Smith