Poster Title
P-12 The Potential of Omega-3 Fatty Acids in Treating Bipolar Disorder through the Metabolic Pathway of Inositol
Abstract
Bipolar disorder is a mental disorder characterized by extreme mood swings. Omega-3-fatty acids have been shown to relieve symptoms of bipolar disorder and are not associated with the negative side effects of lithium and valproate, the two most common treatments of the disorder. However, omega-3-fatty acids’ mechanism of action remains unknown. This study examined the effects of omega-3 fatty acid docosahexaenoic acid (DHA) on intracellular inositol levels of Saccharomyces Cerevisiae. We show that similar to valproate, DHA decreases the growth of Saccharomyces Cerevisiae. We also show that unlike valproate, DHA does not decrease intracellular inositol levels.
Thesis Record URL
https://digitalcommons.andrews.edu/honors/138
Location
Buller Hall
Start Date
2-26-2016 2:30 PM
End Date
2-26-2016 4:00 PM
P-12 The Potential of Omega-3 Fatty Acids in Treating Bipolar Disorder through the Metabolic Pathway of Inositol
Buller Hall
Bipolar disorder is a mental disorder characterized by extreme mood swings. Omega-3-fatty acids have been shown to relieve symptoms of bipolar disorder and are not associated with the negative side effects of lithium and valproate, the two most common treatments of the disorder. However, omega-3-fatty acids’ mechanism of action remains unknown. This study examined the effects of omega-3 fatty acid docosahexaenoic acid (DHA) on intracellular inositol levels of Saccharomyces Cerevisiae. We show that similar to valproate, DHA decreases the growth of Saccharomyces Cerevisiae. We also show that unlike valproate, DHA does not decrease intracellular inositol levels.
Acknowledgments
Dr. Marlene Murray