P-37 Synthesis of Isoxazolines

Buller Hallway

Isoxazolines are organic molecules characterized by their five-membered ring heterocycles containing nitrogen and oxygen, and by their diverse synthetic and biological properties. Isoxazoline derivatives exhibit quite a significance in medicinal chemistry, with reported anti-inflammatory, anti-viral, antifungal, antibacterial, anti-tuberculosis, analgesic and anticonvulsant activity. One group of isoxazoline derivatives, dibenzoazepine tethered isoxazoline derivatives, shows promise as possible future anticancer agents. A study conducted with these compounds tested them against murine osteosarcoma cells, human ovarian cancer cells, human melphalan-resistant multiple myeloma cells and human breast cancer cells. Results from that study showed that the compounds helped to inhibit the invasion, migration and proliferation of some of the cancer cells. This research project attempts to synthesize the isoxazoline structures, to which the dibenzoazepines can be tethered, by cost-effective and efficient means.