Presentation Title

P-32 Screening of Ylidene Rhodanines as Effective Metal Detectors

Presenter Status

Student, Department of Chemistry and Biochemistry; Building Excellence In Science and Technology

Second Presenter Status

Associate Professor of Chemistry, Department of Chemistry and Biochemistry; Founder & Executive Director of Building Excellence in Science and Technology (BEST)

Preferred Session

Poster Session

Start Date

30-10-2015 2:00 PM

End Date

30-10-2015 3:00 PM

Presentation Abstract

In this phase of our project we are conducting broad screens of previously synthesized ylidene rhodanines to explore their metal sensing capabilities. This communication will discuss our results to date. Our long-term goal is development of liquid crystalline ylidene rhodanines for novel applications in histochemistry. Based on ongoing work in Prof Murray’s lab, with undergraduates and high school students, a new ‘green’ approach has been developed for facile synthesis of ylidene rhodanines.

This prior synthesis facilitates exploring new applications for arylidene rhodanines in areas of biomedical and material science. Imaging of metals in human tissue is an important area of biomedical research and technology since metal (especially zinc, iron, and copper) imbalance is increasingly found to be critical in a number of diseases, such as, Alzheimer’s, Parkinson’s and Wilson’s.

Our working hypothesis for the development of liquid crystalline arylidene rhodanine dyes and stains is that in addition to the visualization of cells and their organelles afforded by stains, more information about cellular organization, structure and dynamics could be captured.

Acknowledgments

Kaydra received the Undergraduate Research Scholar Award for this project.

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Oct 30th, 2:00 PM Oct 30th, 3:00 PM

P-32 Screening of Ylidene Rhodanines as Effective Metal Detectors

In this phase of our project we are conducting broad screens of previously synthesized ylidene rhodanines to explore their metal sensing capabilities. This communication will discuss our results to date. Our long-term goal is development of liquid crystalline ylidene rhodanines for novel applications in histochemistry. Based on ongoing work in Prof Murray’s lab, with undergraduates and high school students, a new ‘green’ approach has been developed for facile synthesis of ylidene rhodanines.

This prior synthesis facilitates exploring new applications for arylidene rhodanines in areas of biomedical and material science. Imaging of metals in human tissue is an important area of biomedical research and technology since metal (especially zinc, iron, and copper) imbalance is increasingly found to be critical in a number of diseases, such as, Alzheimer’s, Parkinson’s and Wilson’s.

Our working hypothesis for the development of liquid crystalline arylidene rhodanine dyes and stains is that in addition to the visualization of cells and their organelles afforded by stains, more information about cellular organization, structure and dynamics could be captured.