Presentation Title

P-23 Carboxypeptidase O Regulates Epithelial Cell Migration and Adhesion

Presenter Status

Department of Biology

Second Presenter Status

Department of Molecular Pharmacology

Location

Buller Hallway

Start Date

8-11-2012 3:00 PM

End Date

8-11-2012 5:00 PM

Presentation Abstract

Proteolytic enzymes play important roles in many tissues of the body. We have recently begun to characterize a protease named carboxypeptidase O (CPO), which is found in epithelial cells lining the small intestine and is able to remove C-terminal glutamates from substrate proteins. When CPO was expressed in a model epithelial cell line, it was found to be present in small intracellular vesicles of unknown identity. These CPO-expressing cells exhibited faster migration and greater cell-cell adhesion than control cells. This phenotype and other work suggest a possible role for CPO in cancer mechanisms.

This document is currently not available here.

Share

COinS
 
Nov 8th, 3:00 PM Nov 8th, 5:00 PM

P-23 Carboxypeptidase O Regulates Epithelial Cell Migration and Adhesion

Buller Hallway

Proteolytic enzymes play important roles in many tissues of the body. We have recently begun to characterize a protease named carboxypeptidase O (CPO), which is found in epithelial cells lining the small intestine and is able to remove C-terminal glutamates from substrate proteins. When CPO was expressed in a model epithelial cell line, it was found to be present in small intracellular vesicles of unknown identity. These CPO-expressing cells exhibited faster migration and greater cell-cell adhesion than control cells. This phenotype and other work suggest a possible role for CPO in cancer mechanisms.