Phytochemicals from Croton species of Trinidad and Tobago
Presenter Status
Faculty
Session
B-2
Location
CSH Room 108
Start Date
8-5-2014 11:30 AM
End Date
8-5-2014 12:00 PM
Presentation Abstract
Croton species from the Euphorbiaceae family are best known for the tigliane diterpenes which are tumor promoting. More recently, various other diterpene types have been isolated from Croton. In this presentation, the latex of C. gossypifolius along with the leaves and stems of Trinidadian Croton species, Croton gossypifolius and C. hircinus, were investigated for their secondary metabolites.
A novel cyclic nonapeptide, Crotogossamide, was isolated from the latex of C. gossypifolius along with the flavonoids, quercitrin, myricitrin and afzelin and the amino acid derivative tyramine. Brine-shrimp bioassay-guided fractionation of the crude extract of the leaves of Croton gossypifolius led to the isolation of the known vomifoliol, dehydrovomifoliol and hypoleucolide methyl ester, as well as pinoresinol and kaempferol as minor components. Three novel clerodane diterpenes, Crotohircin A-C were isolated from the leaves of C. hircinus along with the flavonoids artemetin and kaempferol.
The structures of the compounds were elucidated using a combination of the following methods: IR and UV-vis spectroscopy, mass spectrometry, and NMR spectroscopy utilising1H,13C, COSY, 13C-1H HMQC, 13C-1H HMBC, NOESY and DEPT experiments.
Phytochemicals from Croton species of Trinidad and Tobago
CSH Room 108
Croton species from the Euphorbiaceae family are best known for the tigliane diterpenes which are tumor promoting. More recently, various other diterpene types have been isolated from Croton. In this presentation, the latex of C. gossypifolius along with the leaves and stems of Trinidadian Croton species, Croton gossypifolius and C. hircinus, were investigated for their secondary metabolites.
A novel cyclic nonapeptide, Crotogossamide, was isolated from the latex of C. gossypifolius along with the flavonoids, quercitrin, myricitrin and afzelin and the amino acid derivative tyramine. Brine-shrimp bioassay-guided fractionation of the crude extract of the leaves of Croton gossypifolius led to the isolation of the known vomifoliol, dehydrovomifoliol and hypoleucolide methyl ester, as well as pinoresinol and kaempferol as minor components. Three novel clerodane diterpenes, Crotohircin A-C were isolated from the leaves of C. hircinus along with the flavonoids artemetin and kaempferol.
The structures of the compounds were elucidated using a combination of the following methods: IR and UV-vis spectroscopy, mass spectrometry, and NMR spectroscopy utilising1H,13C, COSY, 13C-1H HMQC, 13C-1H HMBC, NOESY and DEPT experiments.